As an essential intracellular antioxidant, reduced glutathione (-L-glutamyl-L cysteinylglycine, GSH) synthesis requires the cystine/glutamate antiporter system (encoded by SLC7A11 ) to import cystine from the environment and reduce it to cysteine
[54,55] GLP-1 is said to exert neuroprotective, cardioprotective, nephroprotective, and immunomodulatory effects by acting through GLP-1 receptors located on many vital organs
Six RCTs utilized matching placebos [26-29,31,35], four used insulin [33,34,36,37], two employed GLP-1RA [30,32], and one trial included both placebo and GLP-1RA in the control groups [25]
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